Affinity Selection MS

Affinity-selection mass spectrometry refers to experiments designed to measure the amount of a given compound bound to a protein. Typically, experiments are done on-line with a combination of size-exclusion and reversed-phase chromatography while the analyte of interest is detected by mass spectrometry.

Ligand Binding Screening
  • Compound Library Screening
  • Inhibitor Screening
  • Natural Products Screening
  • Natural Substrate ID
Plasma Protein Binding
  • Drug-Plasma protein binding screen
  • Quick identification of low binding compounds (<90% bound)
  • Rapid, high-throughput compound mixture screens
Protein-Ligand Binding
  • Competition assays to ID strongest binders
  • Compound mixtures for high-throughput screening
  • Single compounds for rank order binding