Affinity-selection mass spectrometry refers to experiments designed to measure the amount of a given compound bound to a protein. Typically, experiments are done on-line with a combination of size-exclusion and reversed-phase chromatography while the analyte of interest is detected by mass spectrometry.
Ligand Binding Screening
- Compound Library Screening
- Inhibitor Screening
- Natural Products Screening
- Natural Substrate ID
Plasma Protein Binding
- Drug-Plasma protein binding screen
- Quick identification of low binding compounds (<90% bound)
- Rapid, high-throughput compound mixture screens
Protein-Ligand Binding
- Competition assays to ID strongest binders
- Compound mixtures for high-throughput screening
- Single compounds for rank order binding
