Gathering ADME information at the earliest stages of discovery and development helps inform drug program decisions. Taking a compound into clinical development is a multi-million dollar venture and reliable information about the ADME/Toxicology liabilities of a compound helps researchers to select the best option for their program.
Absorption
- CaCO2 Permeability
- P-gp Bi-Directional Permeability
- Solubility
- Stability
Distribution
- Blood-Brain Barrier Penetration
- Cell Uptake
- Drug Transport
- Plasma Protein Binding
- Tissue Distribution
Drug-Drug Interaction
Induction
- Cyp450
- Drug Transporters
- UGT
Inhibition
- Cyp450 Inhibition Screening
- Cyp450 Ki Determination
- Cyp450 Time-Dependent Inhibition
- Drug Transporters
- P-gp Inhibition Screening
- UGT Inhibition Screening
- UGT Ki Determination
Enzyme Kinetics
- Km/Vmax
- Ki
- Intrinsic Clearance
Metabolism
- Cyp Activity
- Cyp Induction
- Intrinsic Clearance
- Km/Vmax
- Metabolite ID
- P-gp Activity
- P-gp Inhibition
- P450 Reaction Phenotyping
- Stability
- UGT Activity
- UGT Inhibition
Stability
- Cytosol
- Hepatocytes
- Microsomes
- Plasma
- S9
- Solution pH
- Storage
- Temperature
Toxicology
Induction
- Cyp450
- Drug Transporters
- UGT
Inhibition
- Cyp450 Inhibition Screening
- Cyp450 Ki Determination
- Cyp450 Time-Dependent Inhibition
- Drug Transporters
- P-gp Inhibition Screening
- UGT Inhibition Screening
- UGT Ki Determination
Tetrogenicity
- Rat Whole Embryo Culture Tetrogenicity Screen
- Zebrafish Embryo Culture Tetrogenicity Screen
