ADME/Tox

Gathering ADME information at the earliest stages of discovery and development helps inform drug program decisions. Taking a compound into clinical development is a multi-million dollar venture and reliable information about the ADME/Toxicology liabilities of a compound helps researchers to select the best option for their program.

Absorption
  • CaCO2 Permeability
  • P-gp Bi-Directional Permeability
  • Solubility
  • Stability
Distribution
  • Blood-Brain Barrier Penetration
  • Cell Uptake
  • Drug Transport
  • Plasma Protein Binding
  • Tissue Distribution
Drug-Drug Interaction
Induction
  • Cyp450
  • Drug Transporters
  • UGT

Inhibition

  • Cyp450 Inhibition Screening
  • Cyp450 Ki Determination
  • Cyp450 Time-Dependent Inhibition
  • Drug Transporters
  • P-gp Inhibition Screening
  • UGT Inhibition Screening
  • UGT Ki Determination
Enzyme Kinetics
  • Km/Vmax
  • Ki
  • Intrinsic Clearance

Metabolism
  • Cyp Activity
  • Cyp Induction
  • Intrinsic Clearance
  • Km/Vmax
  • Metabolite ID
  • P-gp Activity
  • P-gp Inhibition
  • P450 Reaction Phenotyping
  • Stability
  • UGT Activity
  • UGT Inhibition
Stability
  • Cytosol
  • Hepatocytes
  • Microsomes
  • Plasma
  • S9
  • Solution pH
  • Storage
  • Temperature
Toxicology
Induction
  • Cyp450
  • Drug Transporters
  • UGT

Inhibition

  • Cyp450 Inhibition Screening
  • Cyp450 Ki Determination
  • Cyp450 Time-Dependent Inhibition
  • Drug Transporters
  • P-gp Inhibition Screening
  • UGT Inhibition Screening
  • UGT Ki Determination

Tetrogenicity

  • Rat Whole Embryo Culture Tetrogenicity Screen
  • Zebrafish Embryo Culture Tetrogenicity Screen

 

adme_graph_2